Page:NIOSH Manual of Analytical Methods - 9106.pdf/18

METHAMPHETAMINE . . .on Wipes by Liquid-Liquid Extraction: METHOD 9106, Issue 1, dated 17 October 2011 - Page 18 of 31

Table 8b. Precision and accuracy in SIM mode.(1) Compound (D)-Amphetamine

Internal Range(3) µg/ Standard(2) sample Accuracy(4)

Overall(4) Precision

Bias Average

Range

D11-Amp

0.1-30

14.3

0.0412

-0.0750

-0.1153 - -0.0351

D14-Met

0.1-30

10.1

0.0508

-0.0074

-0.0500 - +0.0389

NMPhen

0.1-30

13.3

0.0439

-0.0606

-0.1117 - -0.0318

D11-Amp

0.1-30

21.3

0.0578

-0.1182

-0.1949 - -0.0697

D14-Met

0.1-30

14.4

0.0534

-0.0558

-0.1061 - -0.0170

NMPhen

0.3-30

19.8

0.0387

-0.1338

-0.1775 - -0.0820

D11-Amp

0.3-30

9.1

0.0421

-0.0199

-0.0423 - +0.0157

D14-Met

0.3-30

20.5

0.0503

0.1226

+0.0637 - +0.1883

NMPhen

0.3-30

10.2

0.0449

+0.0260

-0.0075 - +0.0769

MDEA

N-PAmp

0.3-29

10.3

0.0264

-0.0597

-0.0879 - -0.0095

MDMA

D11-Amp

0.1-27

16.2

0.0503

-0.0750

-0.1423 - -0.0292

D14-Met

0.1-0.9(5)

15.4

0.0503(6)

-0.0712

-0.1247 - +0.0032

NMPhen

0.1-27

15.4

0.0496

-0.0722

-0.1136- -0.0108

0.1-10(5)

16.5

0.0379

-0.1030

-0.1414 - -0.0660

D14-Met

0.1-30

9.2

0.0351

-0.0343

-0.0767 - +0.0006

NMPhen

0.1-30

13.6

0.0322

-0.0827

-0.1221 - -0.0403

D11-Amp

0.1-10

17.7

0.0428

-0.1068

-0.1303 - -0.0586

D14-Met

0.1-3

11.3

0.0450

-0.0393

-0.0683 - -0.0205

NMPhen

0.1-3(5)

16.1

0.0449

-0.0871

-0.1279 - -0.0383

D11-Amp

0.1-30

12.8

0.0394

-0.0637

-0.0982 - -0.0433

D14-Met

0.1-30

9.8

0.0495

-0.0051

-0.0375 - +0.0556

NMPhen

0.1-30

11.0

0.0394

-0.0451

-0.0766 - -0.0163

D11-Amp

0.3-30

17.3

0.0402

-0.1073

-0.1496 - -0.0514

D14-Met

0.3-30

11.7

0.0519

-0.0294

-0.0559 - +0.0532

NMPhen

0.3-30

17.0

0.0450

-0.0956

-0.1197 - -0.0576

Caffeine

(L)-Ephedrine

(D)-Methamphetamine D11-Amp

Phencyclidine

Phentermine

Pseudoephedrine

(5)

(1) Backup Data Report [1]. Values are for chlorodifluoroacetyl derivatives and analysis by GC-MS in SIM mode (see Table 6 for MS conditions). Each sample consisted of a pair of 3” × 3” (7.5 cm x 7.5 cm) 12-ply cotton gauze pads. There were 6 replicate samples per concentration level and six concentration levels evaluated from approximately 0.1 to 30 μg/sample. Norephedrine (phenylpropanolamine) was not evaluated in the SIM mode due to breakdown at room temperature storage for several days prior to analysis. (2) Internal Standards, Deuterated: Non-deuterated: D11-Amp = Amphetamine-D11 NMPhen = N-Methyl phenethylamine

D14-Met = Methamphetamine-D14 N-PAmp = N-Propyl amphetamine

(3) Range used for calculation of precision, accuracy, and bias. The entire range studied for all analytes was approximately 0.1 to 30 μg/sample (1×LOQ to 300×LOQ). (4) NIOSH [1995]. NIOSH Technical Report: Guidelines for Air Sampling and Analytical Method Development and Evaluation. By Kennedy ER, Fischbach TJ, Song R, Eller PM, Shulman SA. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 95-117. (5) One or more higher level concentrations were omitted from the computations due to inlier CVs (<0.0200). (6) The overall precision, ŜrT, is an estimate due to inlier precisions (<0.02) at several higher concentration levels.

Method rev. 1.1.1

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition